Drug Information

Calculations of Pediatric Dosage of Digoxin Based on Age and Weight
Age
Digoxin Dose (ug/kg)

Premature
15 to 25

Full term
20 to 30

1 to 24 months
30 to 50

2 to 5 years
25 to 35

5 to 10 years
15 to 30

Over 10 years
8 to 12

(3/5)
Dr. Kaushal’s lecture on Dilutions and concentrations [10/20/09]








Tamiflu (Compounding Liquid from Capsules)
Instructions and Chart are pulled directly from NIH website.
Full Direct Quote (with small omissions and bolding for clarity):
Number of TAMIFLU 75 mg Capsules and Amount of Vehicle (Cherry Syrup OR Ora-Sweet SF) Needed to Prepare the Total Volume of a Compounded Oral Suspension (15 mg/mL)
Total Volume of Compounded Oral Suspension needed to be Prepared
30 mL
40 mL
50 mL
60 mL
Required number of TAMIFLU 75 mg Capsules
6 capsules (450 mg oseltamivir)
8 capsules (600 mg oseltamivir)
10 capsules (750 mg oseltamivir)
12 capsules (900 mg oseltamivir)
Cherry Syrup (Humco) OR Ora-Sweet SF (Paddock Laboratories)
29 mL
38.5 mL
48 mL
57 mL
1. Carefully separate the capsule body and cap and transfer the contents of the required number of TAMIFLU 75 mg Capsules into a clean mortar.
2. Triturate the granules to a fine powder.
3. Add one-third (1/3) of the specified amount of vehicle and triturate the powder until a uniform suspension is achieved.
4. Transfer the suspension to an amber glass or amber polyethyleneterephthalate (PET) bottle. A funnel may be used to eliminate any spillage.
5. Add another one-third (1/3) of the vehicle to the mortar, rinse the pestle and mortar by a triturating motion and transfer the vehicle into the bottle.
6. Repeat the rinsing (Step 5) with the remainder of the vehicle.
7. Close the bottle using a child-resistant cap.
8. Shake well to completely dissolve the active drug and to ensure homogeneous distribution of the dissolved drug in the resulting suspension. (Note: The active drug, oseltamivir phosphate, readily dissolves in the specified vehicles. The suspension is caused by some
f the inert ingredients of TAMIFLU Capsules which are insoluble in these vehicles.)
Put an ancillary label on the bottle indicating "Shake Gently Before Use". [This compounded suspension should be gently shaken prior to administration to minimize the tendency for air entrapment, particularly with the Ora-Sweet SF preparation.]
9. Instruct the parent or guardian that any remaining material following completion of therapy must be discarded by either affixing an ancillary label to the bottle or adding a statement to the pharmacy label instructions.
STORAGE OF THE PHARMACY-COMPOUNDED SUSPENSION:
Refrigeration: Stable for 5 weeks (35 days) when stored in a refrigerator at 2° to 8°C (36° to 46°F).
Room Temperature: Stable for five days (5 days) when stored at room temperature, 25°C (77°F).
Note: This compounding procedure results in a 15 mg/mL suspension, which is different from the commercially available TAMIFLU for Oral Suspension, which has a concentration of 12 mg/mL.
Dosing Chart for Pharmacy-Compounded Suspension from TAMIFLU Capsules 75 mg
Body Weight (kg)
Body Weight (lbs)
Dose(mg)
Volume per Dose 15 mg/mL
Treatment Dose (for 5 days)
Prophylaxis Dose (for 10 days)
≤15 kg
≤33 lbs
30 mg
2 mL
2 mL two times a day
2 mL once daily
16 to 23 kg
34 to 51 lbs
45 mg
3 mL
3 mL two times a day
3 mL once daily
24 to 40 kg
52 to 88 lbs
60 mg
4 mL
4 mL two times a day
4 mL once daily
≥41 kg
≥89 lbs
75 mg
5 mL
5 mL two times a day
5 mL once daily
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=11065 (5/5)